This technology could provide a new wave of insights into many aspects of synaptic development, plasticity, and pathology. Finally, they examined the synaptome in the 5xFAD mouse model of Alzheimer’s disease. They also examined synaptic RNA splicing and expression of long noncoding RNAs, and then profiled the synaptomes of frozen samples from human prefrontal cortex and hippocampus. Once you have submitted your manuscript, it goes through the following editorial process: The manuscript and associated materials are checked for quality and. This suggests that individual dopamine neurons are sensitive. They compared these data with single-nucleus sequencing data and identified genes that were differentially expressed between synapses and nuclei. Nature Neuroscience - Rare rewards amplify dopamine neuron responses, even when conventionally defined prediction errors are identical. Here, the authors discuss emerging trends in network neuroscience, charting a path towards a better understanding of the brain that bridges computation, theory and experiment across spatial. The authors profiled the synaptome of the mouse hippocampus and identified 12 synapse-associated clusters. show that continuous language can be decoded from functional MRI recordings to recover the meaning of perceived and imagined speech stimuli and silent videos. This approach has sufficient sensitivity to detect the small amount of RNA in synaptosome preparations, is compatible with fixed samples (which are required to prevent RNA leakage) and permits detection of both immature and spliced RNAs. developed an assay they call multiple-annealing-and-tailing-based quantitative scRNA-seq in droplets (MATQ-Drop). To overcome previous technical limitations, Niu et al. Single-cell transcriptomic technology has enabled a flurry of neuroscientific discoveries, but the ability to sequence the transcriptomes of single. Single-cell transcriptomic technology has enabled a flurry of neuroscientific discoveries, but the ability to sequence the transcriptomes of single synapses (the ‘synaptome’) has remained elusive. Nature Neuroscience - Single-synapse sequencing.
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